Open up your picture in Photofiltre.
Go to Adjust >> Duotone and make sure your Color 1 is black and your Color 2 is white. It’s makes a difference. You can make your Threshold whatever you want but I made mine 128.
Click the Soften button in your top toolbar once.
Go to Image >> Duplicate and duplicate your base image 3 times. After this in total you should have four copies.
For each of the pictures, go to Adjust >> Replace Color.
To replace the black on your picture with another color, make Color 1: Black and Color 2: whatever color you want to replace the black with.
To replace the white on your picture with another color, make Color 1: White and Color 2: whatever color you want to replace the white with but make sure your second color is contrasting. Don’t make them match. They should be complete opposites.
Make sure the tolerance is 100 when you do this.
Do this for all of your pictures but make sure each picture has different colors.
After you replaced the colors on all your pictures, on each of your pictures using the Magic Wand tool select the face of your person or anything that’s the main focus.
After being selected, go to Filter >> Color >> Colored Layer. Make each face or focal point a different contrasting color.
Go go to one of your duplicates and click Ctrl-A and then Ctrl-C to copy them.
Go to your original picture and go to Edit >> Paste Special Assemble. Assemble it to the right.
Go to another duplicate and click Ctrl-C to copy it and go to your original picture. Go to Edit >> Paste Special >> Assemble >> Bottom.
Now with your last duplicate, copy it and go to your original picture. Click Ctrl-V to paste it and move it into the bottom right corner that is blank.
Go to Adjust >> More Shadows.
Go to Adjust >> Auto Contrast 2 times.